RESUMEN
Background: The relative association between cardiovascular disease (CVD) and mortality in COVID-19 remains unclear. Aim(s): to evaluate the relationship of CVD with in-hospital death among hospitalized patients with Covid-19. Material(s) and Method(s): retrospective cohort study included hospitalized patients aged >= 18 years with confirmed COVID-19 between October and December 2021 in Single COVID -19 department of UMHAT "Alexandrovska". Demographic, clinical and outcome (in-hospital mortality) data were obtained from medical records. All CVD comorbidites were recorded. Multivariate logistic regression models were fitted to quantify the risk and predictors of in-hospital mortality from COVID-19 in patients with these comorbidities. Result(s): 165 patients with a mean age of 64.6+/-15 of whom 44.8% were men were included. In-hospital mortality was 20%. The presence of CVD was associated with increased in-hospital mortality. Mortality risk was higher in patients having hypertension (28.7% vs. 8.7%, p<0.05), coronary artery disease (27.0% vs. 6.5%, p<0.001), previous ischemic stroke (8.1% vs. 1.6%, p< 0.05), valvular heart diasease (16.2% vs. 4.1%), chronic heart failure (29.7% vs. 4.0%, p<0.001). Significant predictors of mortality from COVID-19 in patients with CVD were three vessel disease (HR: 2.04;95% CI 1.42-9.82, p<0.05), previous percutaneous coronary intervention (HR: 5.0;95% CI 2.05-8.56, p<0.05), systolic dysfunction (HR: 5.4;95% CI 1.85-15.76, p<0.05) and advanced heart failure NYHA III-IV (HR: 2.62;95% CI 1.55-4.78, p<0.001). Conclusion(s): COVID-19 patients with CVD comorbidites have a higher risk of in-hospital death. Optimal care and good control of CVD are essential in this patient group.